SLIDE 1
Engaging Scientists in the Adoption of Automation
Coleen Robinson, AstraZeneca
2017 Annual Meeting of the Dial-a-Molecule Network
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Automation Coleen Robinson, AstraZeneca 2017 Annual Meeting of the - - PowerPoint PPT Presentation
Automation Coleen Robinson, AstraZeneca 2017 Annual Meeting of the - - PowerPoint PPT Presentation
Engaging Scientists in the Adoption of Automation Coleen Robinson, AstraZeneca 2017 Annual Meeting of the Dial-a-Molecule Network Why? 2 Agenda Why Automation? What is Effective Automation? Importance of Equipment Evaluation
SLIDE 2
SLIDE 3
- Why Automation?
- What is Effective Automation?
- Importance of Equipment Evaluation
- Automation at AZ
- Range of Approaches
- Range of Equipment
- Range of Users.
- Automation Adoption.
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Agenda
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Increase productivity Enabling unattended operation Increase throughput Minimising human intervention Produce higher quality data Obtain a greater density data And much more ……….
Why?
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What is Effective Automation.
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Importance of Equipment Evaluation
- Understand costs vs benefits
- Resource required
- Engage end users
- Support change management
- Define specific configuration
- Compare alternatives
- Use real-case examples
- Chemistries / processes
- User groups
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Can we automate a process from start to finish on one platform?
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- To evaluate the possibility to investigate process from start to end
- Weighing / Work-up / Filtration
- Use project examples
- Investigate a number of experimental variables, using a statistically designed
set of experiments
Aim
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2-Ethylaminoethanol DMA 90°C Pd-118, DIPEA, tBuOH, Water
SLIDE 9
Fully Automated?
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Conversion (%) Time (hr) 20 40 60 80 100 120
N2
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Planning and Design
Statistical or Kinetic
Reaction Preparation
Solid Handling
Liquid Addition and Reaction Analysis
HPLC GC UPLC
Interpretation
Analytical data
Data Handling Conclusions Reporting
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Would chemists carry out a number of experiments in parallel if it was as easy as carrying out one?
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Do we want to carry out more experiments in parallel or collect more data from each experiment?
Experimental Details and Data
- To investigate using Automated Lab Reactors
(EasyMax/OptiMax) and associated software to automate part of the process of experimental write up and data capture.
- LabConnect Trial on AZ project to:
- Evaluate the ability of scientists to use the EasyMax as a
personal reactor to carry out all chemical operations.
- To enable effective re-use of experimental details and
data.
- To work with vendor and other companies to direct and
exploit the development of the software.
- Engage scientists to help devise a fit for purpose solution.
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2 4 6 8 10 12 14 16 18 Number of Automated Steps Per Experiment Number of data sources recorded from each Experiment Percentage of Equipment Faults Pre-Trial Oct-14 Feb-15 10 20 30 40 50 60 70 80 90 100 Percentage Use of Mettler Equipment Percentage of Reactions With One
- r More PAT Probe
Percentage of Work Carried Out in Parallel
Why?
Increase in the number of parallel reactions?
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2006 2017
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2006 2017
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Data/information from each reaction Number of reactions
Specialist Generalist
Screening FED / DoE Scale-Up PAT Crystallisation Flow
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Data/information from each reaction Number of reactions
Specialist Generalist
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Automation Uptake
- 10
10 30 50 70 90 110 130 150
screens
Asymmetric H2 TM- catalysis
20 40 60 80 100 120 140 160 180
SK233 Amigo
Why?
50 100 150 200 250 300 350
May – Nov 2016