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CHARITABLE INCORPORATED ORGANISATION (CIO) NUMBER - 1159590
Bone Cancer Research Trust
‘Strictly Research’ Grant Applications
BCRT 10th Anniversary Conference 07/05/2016
How can we improve treatment for metastatic osteosarcoma?
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Bone Cancer Research Trust Strictly Research Grant Applications - - PowerPoint PPT Presentation
Bone Cancer Research Trust Strictly Research Grant Applications - - PowerPoint PPT Presentation
Bone Cancer Research Trust Strictly Research Grant Applications 07/05/2016 BCRT 10 th Anniversary Conference CHARITABLE INCORPORATED ORGANISATION (CIO) NUMBER - 1159590 How can we improve treatment for metastatic osteosarcoma? or Does
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Treatment of Osteosarcoma
- Osteosarcoma is the most common primary bone cancer in children and young
adults (age 10-24 years) Current treatment:
- 1. chemotherapy
- 2. surgery
- 3. chemotherapy
The 5 year survival rate for osteosarcoma patients is 60-75%
X-ray showing osteosarcoma tumour in bone
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The problem with metastatic
- steosarcoma…
CT and PET CT scan showing lung metastasis
If the cancer has spread to another site, the survival rate falls as low as 15-30%.
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What affects your chances of recovery from osteosarcoma?
- 1. Rapid tumour growth
- 2. Moving out of bone
- 3. Causing growth of new blood vessels
- 4. Surviving in the blood stream
- 5. Invading another tissue
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How could we improve survival of
- steosarcoma patients?
improve survival rates prevent progression to metastatic osteosarcoma Step 1: Find a protein that speeds up all these steps Step 2: Stop this protein from working and study the effect on disease progression
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We already know some steps that ANGPTL4 speeds up…
Angiopoietin-like 4 (ANGPTL4)
Blood vessel growth ANGPTL4 speeds up bone digestion by osteoclasts
Knowles et al (2010) FASEB J Swales et al (2014) PLoS One
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Question 1: Is ANGPTL4 present in
- steosarcoma tumours?
Tumour Cells Bone
Does the amount of ANGPTL4 relate to disease severity or survival?
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Question 2: How does ANGPTL4 affect the behaviour of osteosarcoma cells?
MG-63 Saos2
- steosarcoma
cells
ANGPTL4
- 1. Tumour growth
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Question 2: How does ANGPTL4 affect the behaviour of osteosarcoma cells?
MG-63 Saos2
- steosarcoma
cells
ANGPTL4
- 4. Surviving in the
blood stream
attached floating
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Question 2: How does ANGPTL4 affect the behaviour of osteosarcoma cells?
MG-63 Saos2
- steosarcoma
cells
ANGPTL4
- 5. Invading
another tissue
24 hours
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Step 2: Stop this protein from working and study the effect on
- steosarcoma
How will this project make a difference?
ANGPTL4:
- present in osteosarcoma
- affects at least 3/5 steps
(??)
Stop ANGPTL4 working and study
- effects on osteosarcoma cells in the lab
- effects on animal models of osteosarcoma
Scientists are developing an ANGPTL4 inhibitor suitable for use in patients.
Step 1: Find a protein that speeds up some (or all) of the 5 steps that cause metastatic osteosarcoma
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How will this project make a difference?
The goal of this project is to find out if ANGPTL4 is a new drug target for
- steosarcoma.
In the long-term this will allow the development of new treatments that will: prevent progression to metastatic osteosarcoma and improve survival rates
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