Designed Antibodies as Weapons against Infectious Diseases Jan - - PowerPoint PPT Presentation

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Nov 01, 2023 482 likes •666 views

Designed Antibodies as Weapons against Infectious Diseases Jan Terje Andersen Department of Biosciences - University of Oslo Department of Immunology - Oslo University Hospital Viruses 3 http://www.public-domain-image.com/free-imagesh

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Designed Antibodies as Weapons against Infectious Diseases

Jan Terje Andersen Department of Biosciences - University of Oslo Department of Immunology - Oslo University Hospital

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Viruses

http://www.public-domain-image.com/free-imagesh ttp://phil.cdc.gov/phil/quicksearch.asp

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Genetic material Protein coat

Photo: Dan Higgins. ttp://phil.cdc.gov/phil/quicksearch.asp

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The winter vomiting bug

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The immune system

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BUBBLE BOY DISEASE

Credit: Baylor College of Medicine Photo Archives

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Antibiotics and anti-viral drugs

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Binding to intruder Binding to cells

The Body’s Foot Soldiers

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Expanding use of therapeutic antibodies

The fastest growing class of bio-therapeutics
The global sale in 2014: >100 billion USD
Autoimmune diseases and cancer
Few against infectious diseases

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Designed foot soldiers

Site-specific modifications Improved binding to cell receptors

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Killing of a virus in cell cultures

Natural antibody Designed antibodies

0% 50% 100%

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The soldiers are patrolling the blood

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Days after injection

Level in blood

Natural antibody

Superior lifespan of antibodies beyond that of natural antibodies

Designed antibodies

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Patient compliance
Economy
Health system