Disease Monitoring James W. Stark, MD, FAAN TISCH MS RESEARCH - PowerPoint PPT Presentation

Disease Monitoring James W. Stark, MD, FAAN TISCH MS RESEARCH CENTER OF NEW YORK 22 ND ANNUAL PATIENT SYMPOSIUM

Timeline of MS Disease Modifying Therapies 1980’s 1990’s 2000’s 2010’s Future Gilenya Ibudilast Aubagio Novantrone Betaseron Tecfidera Ponesimod Rebif ? Plegridy Ozanimod Avonex Lemtrada Tysabri Ofatumumab Ocrevus Copaxone Masitinib Extavia Mayzent Mavenclad

No Evidence of Disease Activity

NEDA No New Symptoms No Physical Exam Changes No MRI Changes Is There More?

What is a Relapse? Blurred Vision Bladder and Bowel Double Vision Weakness Numbness Loss of Balance

Relapse vs Pseudorelapse? Constant Intermittent New Old Focal Generalized

MRI Change in Lesions Contrast Enhancement Neuroquant

Other Testing Cognitive Testing Neurofilament Light Chain Optical Coherence Tomography

NEDA = Disease Control Conclusion NEDA is achievable!!! No Evidence of Need to monitor even without symptoms Disease Activity Doesn’t matter which drug Early effective treatment

THANK YOU! JAMES W. STARK, MD, FAAN