Disease Monitoring James W. Stark, MD, FAAN TISCH MS RESEARCH - - PowerPoint PPT Presentation
Disease Monitoring James W. Stark, MD, FAAN TISCH MS RESEARCH CENTER OF NEW YORK 22 ND ANNUAL PATIENT SYMPOSIUM Timeline of MS Disease Modifying Therapies 1980s 1990s 2000s 2010s Future Gilenya Ibudilast Aubagio Novantrone
TISCH MS RESEARCH CENTER OF NEW YORK 22ND ANNUAL PATIENT SYMPOSIUM
Betaseron
1980’s 1990’s 2000’s 2010’s Future
Timeline of MS Disease Modifying Therapies
Avonex Copaxone
Novantrone
Extavia Tysabri Gilenya Aubagio Tecfidera Lemtrada Ocrevus Ozanimod Ponesimod Ibudilast
Ofatumumab
Masitinib Rebif Plegridy Mayzent Mavenclad
No New Symptoms No Physical Exam Changes No MRI Changes Is There More?
What is a Relapse?
Blurred Vision Weakness Numbness Double Vision Loss of Balance Bladder and Bowel
Relapse vs Pseudorelapse?
Constant Intermittent Focal Generalized New Old
Change in Lesions Contrast Enhancement Neuroquant
Cognitive Testing Neurofilament Light Chain Optical Coherence Tomography
NEDA = Disease Control NEDA is achievable!!! Need to monitor even without symptoms Doesn’t matter which drug Early effective treatment
No Evidence of Disease Activity