SLIDE 1
Jeremi Mizerski Modeling and Simulation of the Cardiovascular System - - PowerPoint PPT Presentation
Jeremi Mizerski Modeling and Simulation of the Cardiovascular System - - PowerPoint PPT Presentation
Jeremi Mizerski Modeling and Simulation of the Cardiovascular System Magdeburg, October 22-24 2018 Roger Bacon (~ 12141294) For the things of this world cannot be made known without a knowledge of mathematics . Opus majus (1267) : A
SLIDE 2
SLIDE 3
- Acute aortic dissection of the ascending aorta is highly lethal,
with mortality ranging between 1–2% per hour early after symptom onset.
- Acute type A dissection is always a surgical emergency.
- Medical management alone is associated with a mortality of nearly 20% by 24 hours,
30% by 48 hours after presentation, 40% by day 7, and 50% by one month.
- Even with surgical repair, mortality rates are 10% by 24 hours,
13% by 7 days, and nearly 20% by 30 days
- The true incidence of acute aortic dissection is difficult to determine,
as many cases may go undiagnosed, but its documented incidence is approximately 2.9 per 100,000 per year
Springer 2007
SLIDE 4
SLIDE 5
SLIDE 6
SLIDE 7
SLIDE 8
SLIDE 9
SLIDE 10
SLIDE 11
SLIDE 12
12
Tunica media is responsible for the viscoelastic properties of the aorta Tunica adventitia is responsible for nutrition of the tunica media
SLIDE 13
¡ Smooth muscle cells:
§ Volume of single muscle cell is ~ 1630 ± 640 µm3 § Density in media ~3,7 ± 0,6×105 cells/mm3
¡ Collagen
§ It is large heterogenous family of about 30 proteins classified as collagens § It is constantly synthesized in smooth muscle cells
¡ Elastin
§ Protein of extremely slow turnover time § It is presented in form of sheets in 71%, fibers 21%, struts 2%
SLIDE 14
14
SLIDE 15
Vasa vasorum Blood stream Diffusion Flow
SLIDE 16
SLIDE 17
Atherosclerotic plaque casts a “shadow” over oxygen diffusion area
SLIDE 18
SLIDE 19
SLIDE 20
¡ Smooth muscle cells require a lot of oxygen to live! ¡ Smooth muscle cells produce a lot of collagen! ¡ Smooth muscle cells do not produce elastin! (or very little)
SLIDE 21
21
Wolinsky&Glagov(1985)
SLIDE 22
22
SLIDE 23
SLIDE 24
¡ Elastin sheets § Cystic media degeneration ¡ Collagen matrix § Marfan syndrome § Ehlers-Danlos syndrome ¡ Smooth muscle cells § Hypoxia
24
SLIDE 25
SLIDE 26
SLIDE 27
27
SLIDE 28
SLIDE 29
29
SLIDE 30
30
Elastin Smooth muscle cells Collagen matrix
SLIDE 31
31
SLIDE 32
32
SLIDE 33
SLIDE 34
Forrest Gump (1986) written by Winston Groom
SLIDE 35