Lenses Beyond Limits Jen Dionne, Stanford University Event Horizon - PowerPoint PPT Presentation

Lenses Beyond Limits Jen Dionne, Stanford University

Event Horizon Telescope, 2019

Earthrise, William Anders, NASA

Co Rentmeester, 1984

Wilhelm Rontgen, 1985

The Inner Life of a Cell, XVIVO, Cellular Visions and Harvard

Tarun Narayan, Andrea Baldi, and Fariah Hayee 40 Narayan*, Hayee*, Baldi, Koh, Sinclair, Dionne, Nature Comm. (2017)

Ashwin Atre 50 nm Atre, Brenny, Coenen, Garcia-Etxarri, Polman, Dionne, Nature Nanotechnology (2015)

Force ( μN ) 1 10 Lay, Goodman, Dionne, Submitted (2019)

mirror plane DNA amino acid Sugar

limonene DNA thalidomide Treats morning nausea Induces birth defects

Approximately 50% of drugs and 40% of agrochemicals are chiral Of these, more than 90% are sold as mixtures of both enantiomers

Can we use light to separate enantiomers?

E B time

chiral nanospecimen nanocoaxial optical fiber Circularly polarized light

R-enantiomer L-enantiomer

L-enantiomer R-enantiomer Right circularly polarized light

Yang Zhao and Amr Saleh

2.5 Pulling force (pN) 0 Right circularly polarized light, 5 nanometer R-enantiomer Y Zhao & J. Dionne et al . ACS Photonics (2016)

2.5 Pulling force (pN) 0 Right circularly polarized light, 5 nanometer R-enantiomer Y Zhao & J. Dionne et al . ACS Photonics (2016)

2.5 Pulling force (pN) 0 Left circularly polarized light, 5 nanometer R-enantiomer

2.5 Pulling force (pN) 0 Left circularly polarized light, 5 nanometer R-enantiomer

1µm 5 µm

λ =770 nm 2 ) Force (pN/100 µ W/ µ m ) 60 pN Light on On orce ( 40 Laser ulling F 20 P Light off Off 0 5 10 15 20 T ime Time (s) Y. Zhao, A. Saleh, J. Dionne, et al., Nature Nanotechnology (2017)

6 Force (pN) 0 R-isomer L-isomer

80 RCP Force (pN/100 µ W/ µ m 2 ) 4 1 LCP Enantiomeric Excess (%) Lateral Force (pN) L-isomer 75 0 With filter R-isomer -6 No filter 70 0 100 0 100 40 40 60 80 100 Tip-aperture separation (nm) Yield (%) z (nm) Y. Zhao, A. Saleh, J. Dionne, et al., Nature Nanotechnology (2017) M. Solomon, J. Hu, J. Dionne, et al. ACS Photonics (2019)