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Matthew Bollom, Vanessa Grosskopf, Samantha Paulsen, Jeff Theisen
Ov Over ervi view w
Background and Motivation Design Specifications Previous Work Semester Goals Staple Fabrication Stapler Design Future Work
Matthew Bollom, Vanessa Grosskopf, Samantha Paulsen, Jeff Theisen Ov - - PowerPoint PPT Presentation
Matthew Bollom, Vanessa Grosskopf, Samantha Paulsen, Jeff Theisen Ov - - PowerPoint PPT Presentation
Matthew Bollom, Vanessa Grosskopf, Samantha Paulsen, Jeff Theisen Ov Over ervi view w Background and Motivation Design Specifications Previous Work Semester Goals Staple Fabrication Stapler Design
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Bla ladder C Canc ncer
Client: Dr. Tracy Downs, Professor of
Urology, University of Wisconsin Clinics
5th most common cancer in United
States 1
Most expensive over time Treatment when cancer invades muscle:
radical cystectomy 2
Urostomy bag Neobladder
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Motivation & n & P Proble lem S m Stateme ment nt
Ureters attached to new bladder via
absorbable sutures
Lengthy procedure Inconsistency between surgeons Metal staples cause stones Minimize subsequent interventions
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De Design S n Specifications ns - S
- Staple
les
Biocompatible Secures ureter to neobladder for a
minimum of 30 days
Able to create water-tight seal Withstands bladder environment Does not damage surrounding tissue Sterile
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De Design S n Specifications ns - S
- Staple
ler
Must be faster and more consistent
compared to sutures
Sterile Firing mechanism must be simple to
- perate
Must form water-tight seal of ureter to
neobladder
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Previous W Work - S k - Staple les
85:15 poly(lactide-co-glycolide) Biocompatible and absorbable Barbs for gripping tissue
http://www.wako-chem.co.jp/specialty/plga/index.htm
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Previous W Work - F k - Fabrication n
Problem: bubbles in material plate and staples
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Previous W Work - T k - Testing ng
staple Problem: bubbles in test specimens, non-physiologically relevant tissue model
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Previous W Work - S k - Staple ler
Problem: not compatible with our staple design
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Seme mester Go Goals ls
Improve staple fabrication – remove
bubbles
Develop stapler prototype Integrate staples with stapler Functional testing of staples and stapler
with physiologically relevant model
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Staple le F Fabrication n
PLGA film deposition via chloroform
evaporation
Film is too flimsy Cannot be compression molded Possible degradation or increased porosity
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Staple le F Fabrication n
Possible approaches
Compression molding in a vacuum Injection molding New aluminum mold
○ Shallow enough so we can squeeze out
bubbles
Plastic mold (PMMA) PMMA staples for functional testing and
validation of staple design
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Staple ler A Approach h
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Staple ler A Approach h
Anvil Ring Clamp Sheath Cartridge Center Bar
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Staple ler A Approach h
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Staple ler V Video
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Future W Work k
Attempt other suggested methods to get
rid of bubbles in material
Fabricate rapid prototype of stapler Integrate staples with stapler Functional testing
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Ackno knowle ledgme ment nts
Dr. Tracy Downs Professor Tompkins Professor Puccinelli Professor Murphy Polymers Lab
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Referenc nces
[1] Bladder Cancer. National Cancer Institute. Retrieved October 17, 2011, from http://www.cancer.gov/cancertopics/types/bladder [2] Bladder Cancer. U.S. National Library of Medicine. Retrieved October 17, 2011, from http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001517/
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