Spatial Analysis 3D Software tools for point pattern analysis in the - - PowerPoint PPT Presentation

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Spatial Analysis 3D Software tools for point pattern analysis in the - - PowerPoint PPT Presentation

Feb 01, 2023 353 likes •803 views

Spatial Analysis 3D Software tools for point pattern analysis in the nervous system (and beyond) Benjamin Reese Neuroscience Research Institute and Department of Psychology University of California at Santa Barbara The mature retina

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Spatial Analysis 3D—Software tools for point pattern analysis in the nervous system (and beyond)

Benjamin Reese Neuroscience Research Institute and Department of Psychology University of California at Santa Barbara

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The mature retina contains multiple types of nerve cells positioned in distinct cellular layers: photoreceptors interneurons ganglion cells

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Fate determination Migration Process outgrowth and target recognition Synaptogenesis Cell death

Events that transform the immature neuroepithelium into a differentiated retina:

→

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from Dorsky et al., 1997 from Wikler and Rakic, 1994

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Fate determination Cell death Dispersion

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Real Random

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Real Random

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Strain-specific effective radius Strain-invariant effective radius Low Density Low Density High Density High Density

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A B6

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A B6

100 µm

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Cholinergic amacrine cells dmin simulation Random simulation

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Challenges for 3D Analysis

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Challenges for 3D Analysis

  • Computation
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Challenges for 3D Analysis

  • Computation
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Challenges for 3D Analysis

  • Computation
  • Visualization
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Acknowledgements

Mary Raven—UCSB Dan Lofgreen—Channel Islands Consulting Stephen Eglen—Cambridge University

Funded by the NIH:

National Institute of Mental Health National Eye Institute

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