WEDNESDAY, MAY 22 POSTER PRESENTATIONS Presenting Author Presenting - - PowerPoint PPT Presentation

WEDNESDAY, MAY 22 POSTER PRESENTATIONS

Abstract Title Abstract # Presenting Author Last Name Presenting Author First Name Category Presentation Date

Development of a Novel Liver Targeting Formulation for Nucleic Acid Delivery 1577 AL Fayez Nojoud Drug Delivery and Pharmaceutical Technology Wed Empagliflozin Improves Diastolic Function through the Suppression of NLRP3 Inflammasome in an Experimental Model

• f Heart Failure with Preserved Ejection Fraction

1565 Almaayah Zaid Biomedical Sciences Wed Trastuzumab-DM1 affects the vasculature of tumour microenvironment causing enhanced delivery of 64Cu-NOTA- pertuzumab Fab visualized by MicroPET/CT imaging 1404 Al-saden Noor Biomedical Sciences Wed Amino acid functionalized nanodiamonds as gene carriers: investigation of cellular uptake and intracellular trafficking

• f the prototype and design optimization for improved efficacy

1384 Alwani Saniya Drug Delivery and Pharmaceutical Technology Wed Water Insoluble Amphiphilic Polymers for Safe and Efficient Delivery of siRNA to Chronic Myeloid Leukemia Cells 1555 Ansari Aysha Drug Delivery and Pharmaceutical Technology Wed Pharmacokinetics Assessment of the Vaccine Adjuvant P60, a Cell-Penetrating FOXP3 Binding Peptide, using SPECT/CT 1460 Bergamo Marta Pharmacokinetics and Pharmacodynamics Wed Evaluation of an Anti-Mesothelin Aptamer Panel for the Diagnosis of Pancreatic Cancer 1506 Biniecka Paulina Drug Delivery and Pharmaceutical Technology Wed Pharmacokinetics of IDR1002 via Various Routes of Administration Using SPECT/CT 1468 Blackadar Colin Pharmacokinetics and Pharmacodynamics Wed A 99mTc Labeled Tetrazine for In Vivo Pretargeted Imaging. 1478 Bohrmann Lennart Drug Delivery and Pharmaceutical Technology Wed Phospholipid-free small unilamellar vesicles for liver-targeted drug delivery 1595 Böttger Roland Drug Delivery and Pharmaceutical Technology Wed Nanoparticle Mediated Non-Viral Delivery of Messenger RNA in Human T cells Towards Development of CAR T Therapy 1570 Brown Andrew Drug Delivery and Pharmaceutical Technology Wed Characterization of the effects of SUMOylation on the orphan nuclear receptor Nur77 1459 Caissy Jean-Alexandre Biomedical Sciences Wed Skeletal Muscle Ketone Body Metabolism Regulates Glycemia During Experimental Obesity 1464 Chahade Jadin Biomedical Sciences Wed Recombinant B7-1 (CD80) preparation towards probing the druggable sites of B7-1 1480 Chen Rui Biomedical Sciences Wed Inhibiting Soluble Epoxide Hydrolase Protects the Heart Against Ischemia/Reperfusion Injury by Attenuating the NLRP3 Inflammasome Pathway 1586 Darwesh Ahmed Biomedical Sciences Wed

Targeting Endoplasmic Reticulum (ER) Quality Control in Dysregulated Prostate Cancer Cells: Understanding Enterolactone’s Cellular Effects 1487 De Silva Franklyn Biomedical Sciences Wed Externally Activated Cork-Shell Microcapsules for On-Demand Drug Delivery 1503 Dorogin Jonathan Drug Delivery and Pharmaceutical Technology Wed Development of a CFSE-Equivalent for CyTOF (CERC) Reagent 1469 Encinas Casas Adria Drug Delivery and Pharmaceutical Technology Wed 111In-Radiolabeling of Human Insulin using tetrazine-TCO bioorthogonal reaction and its in vivo evaluation 1533 Engudar Gokce Drug Delivery and Pharmaceutical Technology Wed Thermosensitive liposomes loaded with various chemotherapeutic agents: a comparison of formulation and release characteristics 1596 Epp-Ducharme Brittany Drug Delivery and Pharmaceutical Technology Wed Efficacy and Toxicity Assessment of a Novel Colistin Formulation to Treat Pseudomonas Aeruginosa Lung Infections 1507 Esposito Tullio Drug Delivery and Pharmaceutical Technology Wed Microfluidic approaches for the production of monodisperse, superparamagnetic microspheres in the low micrometer size range 1587 Geczy Reka Drug Delivery and Pharmaceutical Technology Wed Glucose-responsive Glucagon Delivery via Microneedle Patch for Prevention of Hypoglycemia 1536 GhavamiNejad Amin Drug Delivery and Pharmaceutical Technology Wed Cardiac Glucose Oxidation Rates are Impaired and a Possible Pharmacological Target for Mitigating Heart Failure in Barth Syndrome 1500 Greenwell Amanda Biomedical Sciences Wed Potential Protective Effects of Sea Cucumber Extract in Animals with Ethanol-Induced Dysfunction 1479 Head Nicole Biomedical Sciences Wed Development and characterization of a human – based bronchial epithelium model for infection studies 1409 Hedtrich Sarah Biomedical Sciences Wed Endogenous opioid analogue with improved safety profile for chronic pain management 1599 Hohenwarter Lukas Drug Delivery and Pharmaceutical Technology Wed Chemotherapy-Induced Nausea and Vomiting (CINV) in Colorectal Cancer (CRC) Patients Undergoing FOLFOX Chemotherapy: A Retrospective Chart Review Comparing Two Ontario Hospitals 1644 Hooda Naushin Clinical Sciences & Pharmacy Practice Wed Nanoemulsions for the delivery of poorly water-soluble drugs 1489 Khalid Mohamed Nabil Drug Delivery and Pharmaceutical Technology Wed Medical Cannabis Oil Products: Quality, Biochemistry and Clinical Relevance 1688 Kotra Lakshmi Clinical Sciences & Pharmacy Practice Wed Jadomycin B and S prevent the formation of mammospheres originating from breast cancer stem cells 1425 Lee Joonho (Jimmy) Pharmacokinetics and Pharmacodynamics Wed Assay Development for Screening Inhibitors of Dihydrodipicolinate Synthase from Campylobacter jejuni 1461 Majdi Yazdi Mohadeseh Pharmaceutical & Analytical Chemistry Wed Simultaneous Quantification of 17 drugs in Breast Milk by Liquid Chromatography Coupled to Mass Spectrometry (LC- MS/MS) 1472 Monfort Anaelle Pharmaceutical & Analytical Chemistry Wed

Inhalable Antimicrobial-loaded Microspheres for the Treatment of Lung Diseases 1537 Nahrstedt Jessica Drug Delivery and Pharmaceutical Technology Wed DDDPlusTM Application at the Early Stage of Drug Development 1455 Njoku Juliet Obianuju Drug Delivery and Pharmaceutical Technology Wed SAR studies and molecular target identification of Clionamine B analogues: autophagy stimulating and Mtb clearing aminosteroids 1601 Persaud Rosanne Pharmaceutical & Analytical Chemistry Wed Development and Validation of a Sensitive Liquid-Chromatography Tandem Mass-Spectrometry Assay with Dual Ion Source Ionization to Simultaneously Quantify Mycophenolic Acid, Mycophenolic Acid Glucuronide, and Mycophenolic Acid Acyl-Glucuronide in HepaRG Cell Culture Medium 1387 Rong Yan Pharmaceutical & Analytical Chemistry Wed Characterization and modulation of the type 1 cannabinoid receptor in a rat model of absence epilepsy 1542 Smolyakova Anna Maria Biomedical Sciences Wed Effect of co-enzyme Q10 and diltiazem on metabolism of adenosine 5’-triphosphate and guanosine 5’-triphosphate in red blood cell in rats 1419 Yeung Pollen Pharmacokinetics and Pharmacodynamics Wed

THURSDAY, MAY 23 POSTER PRESENTATIONS

Abstract Title Abstract # Presenting Author Last Name Presenting Author First Name Category Presentation Date

Comparative biochemical analysis of various berries collected from fogo island and chemical analysis of lingonberries using high performance liquid chromatography 1519 Ahmed Farhana Pharmaceutical & Analytical Chemistry Thursday The Design of Polymeric Microneedles for the Delivery of Sensors for Real-Time Physiological Monitoring 1547 Babity Sam Biomedical Sciences Thursday Cannabinoid Receptor Expression in Facial Skin Ganglion Neurons in Female Rats 1556 Benbow Tarique Biomedical Sciences Thursday Characterizing the Upregulation of Reduced Folate Carrier (RFC) by Vitamin D Receptor at the Blood-Brain Barrier 1420 Georgiou Constantine Biomedical Sciences Thursday Improvement of Radiofrequency Ablation in Liver Cancer: Cellular Uptake of Gold Nanoparticles in Cellular Model 1667 Guiho Amelie Drug Delivery and Pharmaceutical Technology Thursday β-glucuronidase enzymes in human tissue lysates: evidence for human intestinal tissue βG activity and constitutive (non-bacterial) entero-hepatic recycling 1585 Haefling Brandon Biomedical Sciences Thursday Protein replacement therapy in transglutaminase 1 skin models: Topically applied thermoresponsive nanogels successfully mitigate the ARCI phenotype 1408 Hedtrich Sarah Drug Delivery and Pharmaceutical Technology Thursday Predicting breast cancer drug treatment response with integrated genomic and chemical properties using machine learning 1476 Huang Shujun Pharmacokinetics and Pharmacodynamics Thursday

Abstract Title Abstract # Presenting Author Last Name Presenting Author First Name Category Presentation Date

Targeting interleukin-1β signaling as a potential therapeutic strategy to protect islet β-cells from amyloid toxicity in diabetes 1683 Hui Queenie Biomedical Sciences Thursday Preparation and evaluation of caffeine drug release rate from Albumin microcapsules 1485 Khalid Mohamed Nabil Drug Delivery and Pharmaceutical Technology Thursday Phytocannabinoids, Decarboxylation and Receptor Responses: A Means to Consistent Medical Cannabis Product Quality 1443 Kotra Lakshmi Pharmaceutical & Analytical Chemistry Thursday Translational and post-translational modifications of human uridine diphosphate glucuronosyltransferase 1A6 (UGT1A6) regulate enzyme activity via glycosylation 1535 Liu Yuejian Biomedical Sciences Thursday Injectable Starch Nanoparticle (SNP) and O-Carboxymethyl Chitosan (CMCh) Schiff Base Hydrogels for the Intranasal Delivery of Anti-Psychotic Therapeutics 1520 Majcher Michael Drug Delivery and Pharmaceutical Technology Thursday Assessing the pharmacology of select plant-derived cannabinoids on the type 2 cannabinoid receptor 1539 Mohamed Kawthar Biomedical Sciences Thursday Development of a Self-Assembling Polymer-Drug Nanoparticle Platform using Copper-Catalyzed Azide-Alkyne Cycloaddition Click Chemistry 1576 Nguyen Anne Drug Delivery and Pharmaceutical Technology Thursday Estimating excipient effects on dissolution profiles of solid solutions using DDDPlusTM 1458 Njoku Juliet Obianuju Drug Delivery and Pharmaceutical Technology Thursday Iron Oxide Nanoparticles as Drug Carrier of Salinomycin for Glioblastoma Therapy 1566 Norouzi Mohammad Drug Delivery and Pharmaceutical Technology Thursday Smartphone Apps Targeting Medication Adherence: Content Analysis of User Reviews 1390 Park Jamie Clinical Sciences & Pharmacy Practice Thursday Liposomal delivery of an immunomodulating agent to the tumour microenvironment 1594 Pauli Griffin Drug Delivery and Pharmaceutical Technology Thursday Evaluation of Dalteparin and Enoxaparin Accumulation in Renal Impaired Patients 1467 Poulin Patricia Clinical Sciences & Pharmacy Practice Thursday Detection of inflammatory and angiogenic markers in human placental tissue 1584 Price Hayley Biomedical Sciences Thursday Engineering 89Zr-labeled amino acid functionalized diamond nanoparticles for gene delivery: method development,

• ptimization, stability study and biodistribution studies

1439 Rai Raj Drug Delivery and Pharmaceutical Technology Thursday Implementation of neurocritical care is associated with changes in sedative and analgesic prescribing in traumatic brain injury 1538 Rebic Nevena Clinical Sciences & Pharmacy Practice Thursday Inhibitory Effects of P-Cresol Toward Mycophenolic Acid Glucuronidation in HepaRG Cells 1388 Rong Yan Pharmacokinetics and Pharmacodynamics Thursday Investigation of Polymeric Coatings to Improve Intestinal Delivery of Aqueous Peptides 1573 Saxena Tanya Drug Delivery and Pharmaceutical Technology Thursday

Abstract Title Abstract # Presenting Author Last Name Presenting Author First Name Category Presentation Date

On the usefulness of sink index for characterizing the degree of nonsinkness in in-vitro dissolution testing of supersaturating formulations 1451 Schver Giovanna Drug Delivery and Pharmaceutical Technology Thursday 19-(S/R)Hydroxyeicosatetraenoic Acid is a Novel Endogenous Inhibitor of Cytochrome P450 1B1 in Enantioselective Manner 1492 Shoieb Sherif Pharmacokinetics and Pharmacodynamics Thursday In vivo predictive Dissolution: A systematic study of excipient and manufacturing variables. 1496 Silva Daniela Drug Delivery and Pharmaceutical Technology Thursday Co-encapsulation of Curcumin with SN-38 leads to Increased Encapsulation Efficiency of SN-38 in PCL-b-PEO Polymeric Nanoparticles 1438 Silverman Lisa Drug Delivery and Pharmaceutical Technology Thursday Androgen recycling as a mechanism for progression to castration resistant prostate cancer 1571 Smith Alexander Biomedical Sciences Thursday Combination delivery of siRNA-encapsulated solid lipid nanoparticles and hydroxychloroquine from an intravaginal ring as prevention for HIV 1700 Traore Yannick Drug Delivery and Pharmaceutical Technology Thursday Developing a Dried Blood Spot Assay for Detecting Prenatal Cannabis Exposure in Newborns 1540 Vuong Stephanie Pharmaceutical & Analytical Chemistry Thursday Pharmacokinetic evaluation of novel bone-targeting Parathyroid Hormone conjugates to treat Osteoporosis 1465 Wajda Benjamin Drug Delivery and Pharmaceutical Technology Thursday Evaluation of a Novel Lanthanide Compound (La(XT)) in an OVX Rat Model of Osteoporosis 1372 Wasan Kishor Drug Delivery and Pharmaceutical Technology Thursday The Zebrafish: An Emerging Preclinical Screening Tool for Nanomedicines 1603 Witzigmann Dominik Drug Delivery and Pharmaceutical Technology Thursday Transcriptome-wide identification of transient RNA G-quadruplexes in human cells 1579 Yang Sunny Biomedical Sciences Thursday Alterations in Chemokine Receptor CCR5 Activity Influence Tumor Cell Biology in Human Intra- and Extra-hepatic Cholangiocarcinoma Cell Lines 1531 Yang Jiaqi Biomedical Sciences Thursday Assessment of novel type 1 cannabinoid receptor positive allosteric modulators in vitro and in vivo 1562 Zagzoog Ayat Drug Delivery and Pharmaceutical Technology Thursday Phenformin hydrochloride-loaded liposomes for anticancer therapy 1561 Zhao Lisha Drug Delivery and Pharmaceutical Technology Thursday