Enterprise Vocabulary Development in Protege/OWL: Workflow and - PowerPoint PPT Presentation

Enterprise Vocabulary Development in Protege/OWL: Workflow and Concept History Requirements Sherri de Coronado Gilberto Fragoso Protégé Workshop – Jul 8, 2004

Topics • Background • NCI Thesaurus conversion to OWL • Requirements for Using Protégé-OWL for NCI Thesaurus • Progress / Pilot Testing

NCI EVS • Services and resources addressing NCI needs for controlled vocabulary http://ncicb.nci.nih.gov/core/EVS • Goal: Integration by Meaning • Collaboration between NCI OC and NCICB – Cancer Information Products and Systems (PDQ and Cancer.gov) – caCORE and Community portals

NCICB builds on EVS via caCORE Infrastructure https://ncicb.nci.nih.gov/core EVS- NCICB Portals dependent ฀ caIm age Application ฀ CGAP s ฀ caM OD ฀ MycaBIO caCORE caBIO API EVS Package EVS Production caBIO Servers Other caBIO XM L/RPC caBIO Packages Release Repository caBIO Hx servers caDSR Thesaurus caBIO API EVS PAckage caDSR RM I Release Repository caDSR M etathesaurus server

NCI Thesaurus • Public domain, open content license • Broad coverage of cancer domain – Neoplastic disease, Findings and Abnormalities, Anatomic Structures, Agents, Cancer-related genes, Gene products, etc. • DL based using Apelon’s Ontylog • 34,000+ “Concepts” – 20 hierarchies, 19 kinds – “Roles” establish semantic relationships between Concepts – “Properties” state facts about Concept • Concept history

NCI Thesaurus Production Environment NCI Thesaurus W orkflow Conflict Detection Classification and Resolution Lead Editor TDE � W ork M anager Client � Editing Application W ork List Baseline � Conflict Detection/Resolution Generation � DB Schem a Change - M aster NCI Baseline Set - M aster History Hx W ork Assign m ent Hx Validation NCI Thesaurus Editing Environm ent External Testing Schem a Hx Candidate Schem a Release NCI Thesaurus Test DTS Servers Schem a Production Release Individual Editors’ TDE � W orkflow Client Release � Editing Application � DB Schem a Hx - Current NCI Baseline NCI Thesaurus - Local History Production DTS Servers

Ontylog to OWL Conversion • Why OWL Lite for the conversion? – To make it available in a non-proprietary form – To enable a wider audience to use it. – Current Thesaurus has fairly simple semantic constructs

Mapping the Semantics • Kinds and Concepts modeled as Classes • Ontylog Role becomes ObjectProperty with Domain and Range (restrictions) • Ontylog Property becomes AnnotationProperty • Some and All translated as SomeValuesFrom and AllValuesFrom

Requirements for Using Protégé- OWL • Concept History • Search Capabilities • Various Edit Actions / User Interface • Workflow Management Functions • Vocabulary Server (DTS or something new?)

Concept History Issues • Certain editing actions result in retirement of Thesaurus codes – Merge, Split, Retirement • Dependent applications/users require a mechanism to retrieve data coded with Thesaurus codes that have been retired • Tracking complex edit actions in History allows dependent apps/users to query for replacement codes

Search Capabilities • Must operate on various term-containing properties, not just on class names – Good search capability critical for users and editors – Search on terms in annotation properties • Configurable, e.g. for default settings

Edit Actions / User Interface • Support various editing actions – Merge – Split – Pre-retirements (by editor) – Retirement (by manager)

Split Edit Action • Generates a new class – History must record an association between the split and the new class • Properties and subclasses must be reviewed and resolved between the new and existing classes • References to existing class must be reviewed and edited if necessary • Must have GUI support

"Split" GUI Panel

New Class in Tree

Merge Edit Action • Existing class is merged into another and retired – History must record a retirement action, and an association between the surviving and the retired class • Properties must be copied, properties of retired class must be recorded (AnnotationProperty), subclasses must be moved to surviving class, retired class must be re-treed • References to retired class must be reviewed and edited if necessary • Must have GUI support

Merge Window

Select Surviving Class, Drop into Rightmost Pane Swap

Retirement Actions • Editors flag class for pre-retirement – Review and remove/modify restrictions and subclasses – State is annotated: super and subclasses, restrictions, references – References to class eliminated – Class is re-treed to holding bin, remaining subclasses re- treed under class' parent • Manager confirms retirement – Class is re-treed to retirement bin – No programmatic Undo support – History records the retirement action, and associations to the class' parent classes • GUI support for pre- and retirement

Restrictions Subclasses Pre-Retirement GUI

Workflow Management Needs • Worklist assignments by manager and tracking of worklist items by editors • Assignment of editing/review privileges • Locking and unlocking of database (or server) for editing • Review and consolidation of editing changes by manager • Generation of reports by manager or editors

Other Workflow Needs • Import Changesets by Manager and export Changesets by Editor (maybe) • Export of database “Baseline” by manager – Development or Release baselines – Release export results in auto history export • Configuration/constraints of environment • Backup and Restore of database to archive by manager

Data Handling Issues • Changed items should be flagged for review • Consolidation/conflict resolution step involves accepting or rejecting changes to concepts/classes made by editors • Class/instance deletion is restricted • All edit actions processed in parallel for history

Progress/ Pilot Testing • NCI Protégé/OWL extension in progress – NCIOWLClsesTab to support workflow/ history as shown • Pilot to Evaluate Protégé-OWL for editing and semantic capabilities – 2-3 months: Kevric, NCI, Stanford, Uvic

EVS Team EVS NCI OC – oncology, pathology, pharmacy Margaret Haber Larry Wright NCI CB – biology, operations Sherri de Coronado Gilberto Fragoso Frank Hartel Apelon, Inc. Northrop Grumman, Inc. Aspen, Inc. Kevric Corporation Jim Oberthaler SAIC Stanford Medical Informatics