PRECISION CRITICAL CARE H OW DATA CAN HELP US FIND THE ZEBRA IN A - - PowerPoint PPT Presentation

▶

Jun 01, 2023 369 likes •512 views

PRECISION CRITICAL CARE H OW DATA CAN HELP US FIND THE ZEBRA IN A HERD OF HORSES D AVID M ASLOVE , MD, MS, FRCPC D EPARTMENT OF C RITICAL C ARE M EDICINE Q UEEN S U NIVERSITY SEAMO I NNOVATION S HOWCASE K INGSTON , O NTARIO J UNE 6, 2018

SLIDE 1

PRECISION CRITICAL CARE

HOW DATA CAN HELP US FIND THE ZEBRA IN A HERD OF HORSES

DAVID MASLOVE, MD, MS, FRCPC DEPARTMENT OF CRITICAL CARE MEDICINE QUEEN’S UNIVERSITY KINGSTON, ONTARIO

SEAMO INNOVATION SHOWCASE JUNE 6, 2018

SLIDE 2

“When you hear hoofbeats, think of horses not zebras.”

—Dr. Theodore Woodward

SLIDE 3

46 KB 59 KB

DATA TO ENABLE DISTINCTIONS

SLIDE 4

DATA TO ENABLE DISTINCTIONS

SLIDE 5

DATA TO ENABLE DISTINCTIONS

SLIDE 6

E & B Genomics Physiology

DATA TO ENABLE DISTINCTIONS PRECISION

SLIDE 7

E & B Genomics Physiology

COmbining Novel Datasets to Understand Illness Trajectory

www.conduitlab.org

SLIDE 8

100 200 300 400 Day 0 Day 3 Day 7 Day 14 Day 21 Day 28

Genomics

Placebo Lactoferrin

! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! !

Transcriptomic clusters of sepsis Transcriptomic effects of lactoferrin

SLIDE 9

Physiology BedmasterEX 20TB

Centre for Advanced Computing

SLIDE 10

0.000

0.025 0.050 0.075 0.100 −2 2 4 Time(hours) SDNN status

Physiology

●
●
●
● ●
●
●
● ●
●
0.0020

0.0025 0.0030 0.0035 0.0040 −2 2 4 Time(hours) SDNN status

Patient1 − SDTT

Courtesy of V. Tolls

Phenylephrine infusion

SLIDE 11

E & B

STEPS STAIRS HEART RATE SLEEP 125 250 375 500

SLIDE 12

PRECISION CRITICAL CARE

NEED FOR PRECISION AVAILABILITY OF DATA

Right Patient Right Treatment Right Time

SLIDE 13

QUESTIONS & COMMENTS

@DavidMaslove david.maslove@queensu.ca