Recent advances in gastrointestinal Mapping and Modelling Tim - PowerPoint PPT Presentation

Recent advances in gastrointestinal Mapping and Modelling Tim Angeli, PhD Auckland Bioengineering Institute University of Auckland, New Zealand

Slow Waves and Gastric Contractions

Previous Slow Wave Studies

High-Resolution (HR) Electrical Mapping Du et al, Ann Biomed Eng 2009; 37:839-46 O‘Grady et al, Am J Physiol Gastrointest Liver Physiol 2010; 299:G585-92

GEMS Software Package Yassi et al, BMC Gastroenterol 2012;12:60. Paskaranandavadivel et al, IEEE Trans Biomed Eng 2012; 59:882-89.

Recent Mapping Cohort 1) Healthy Controls • n = 21 patients • Devoid of gastric pathology 2) Gastroparesis • n = 12 patients • Diagnosed with medically refractory gastroparesis 3) Chronic Unexplained Nausea and Vomiting (CUNV) • n = 8 patients • Diagnosed with CUNV Angeli et al, Gastroenterology 2015; 149:56-66.e5. O‘Grady et al, Gastroenterology 2012; 143:589-98. O‘Grady et al, Am J Physiol 2010; 299:G585-92.

Healthy Control: Normal Activity Angeli et al, Gastroenterology 2015; 149:56-66.e5. O‘Grady et al, Gastroenterology 2012; 143:589-98.

Gastroparesis Abnormal Initiation: Unstable O‘Grady et al, Gastroenterology 2012; 143:589-98.

CUNV Abnormal Initiation: Stable Angeli et al, Gastroenterology 2015; 149:56-66.e5.

Updated Dysrhythmia Classification Angeli et al, Gastroenterology 2015; 149:56-66.e5. O‘Grady et al, Gastroenterology 2012; 143:589-98.

Multi-Scale Mathematical Modelling Multiscale Mathematical Model Du et al. WIREs Syst Biol Med 2013;5:481-93.

Multi-Scale Mathematical Modelling Du et al. WIREs Syst Biol Med 2013;5:481-93.

Tissue-Level Slow Wave Propagation Wild Type Knockout Du et al. Biophys J 2010;98(9):1772-81.

Organ-Level Slow Wave Propagation Du et al. Biophys J 2010;99(9):2784-92.

Body-Surface Slow Wave Potentials Du et al. Biophys J 2010;99(9):2784-92.

Dysrhythmia in Gastroparesis

Conclusions • High-resolution mapping and multi-scale modelling have provided improved insights into gastrointestinal regulation, function, and health. • Engineering principles can be highly valuable in improving our understanding of the processes and mechanisms of digestion. • These data and methods may provide an enhanced basis for the research and development of functionally-targeted food and nutrition.

Horizons: Diagnostics Bedside Tests Endoscopic Diagnosis Clinical Translation

Horizons: Therapy Ablation Pacing model experimental

Horizons: Functional Nutrition Brit. J. Anaesth. 2000; 84(3):367-71. Dig. Dis. Sci. 2005; 50(10):1889-97. Am. J. Physiol. Gastrointest. Liver Physiol. 2003; 284:G481-9.

Team A/Prof Leo Dr Peng Du Dr Greg O’Grady Prof John Windsor Cheng Dr Tim Angeli Dr Niranchan Paskaranandavadivel Funding