The DiaGene: a prospective case-control study Sunny Singh Badal MD, - PowerPoint PPT Presentation

The DiaGene: a prospective case-control study Sunny Singh Badal MD, PHD student Department: Vascular Medicine

Type 2 Diabetes Mellitus (T2DM)  RIVM: Rising prevalence and incidence  Prevalence 2017: 1135100  Incidence 2017: 60200   Still high percentage develop complications

Methods  DiaGene study - Multicenter prospective case-control study - DM2 cases, healthy controls - Eindhoven: Maxima Medisch Centrum, Catharina Hospital, Diagnostic Center Eindhoven (General practioners) Van Herpt, Thijs T. W. et al. “Introduction of the DiaGene Study: Clinical Characteristics, Pathophysiology and Determinants of Vascular Complications of Type 2 Diabetes.” Diabetology & Metabolic Syndrome 9 (2017): 47. PMC . Web. 16 July 2017

Methods DM , diabetes mellitus; MODY, Maturity-Onset Diabetes of the Young; Latent Auto-immune Diabetes of the Adult

Statistics Endpoints Macrovascular complications: Ischemic brain disease, ischemic heart disease. PAD etc. Microvascular complications  Retinopathy, nephropathy, neuropathy, composite endpoint Genetic associations with incident and prevalent complications will be assessed