Validation of navigated beta-probe imaging with PET/CT-generated - - PowerPoint PPT Presentation

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Validation of navigated beta-probe imaging with PET/CT-generated - - PowerPoint PPT Presentation

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chair for computer aided medical procedures (CAMP) | campar.in.tum.de department of nuclear medicine (MRI|NM) | www.nuk.med.tum.de Validation of navigated beta-probe imaging with PET/CT-generated activity surfaces New approach in

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chair for computer aided medical procedures (CAMP) | campar.in.tum.de department of nuclear medicine (MRI|NM) | www.nuk.med.tum.de

03 July 2007

Chair for Computer Aided Medical Procedures Department of Computer Science | TU Munich Department of Nuclear Medicine Klinikum rechts der Isar | TU Munich

Wendler, T.; Traub, J.; Ziegler, S.I.; Navab, N. In collaboration with Intra-Medical Imaging LLC

Validation of navigated beta-probe imaging with PET/CT-generated activity surfaces

New approach in radio-guided resection for FDG-positive tumors

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Background

  • Lately β-probes have been proposed for intra-
  • perative localization of residual cancer cells

after resection, given their high accuracy and sensitivity1.

  • The combination of them with spatial localization

systems offers new possibilities for intra-

  • perative nuclear imaging and radio-guided

surgery2.

1 E.g. Daghighian et al. 1994, Raylman et al. 1996, Levin et al. 2003, … 2 Wendler et al. 2006, Kishenkov et al. 2007, Wendler et al. 2007

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x1, y1, z1, c1 x2, y2, z2, c2 x3, y3, z3, c3

...

… xn, yn, zn, cn

Background

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Adapted from Wendler et al. 2006

Background

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Adapted from Wendler et al. 2006

Background

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Objectives

  • Find ways to validate introduced technology.
  • Generation of beta-emission surfaces from a

preoperative PET/CT.

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Materials

ART2 Cameras & DTrack, ART GmbH β-probe & NodeSeeker, Intra-Medical Imaging LLC Biograph Sensation 16 PET/CT, Siemens Ad hoc phantom

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Methods

Phantom preparation PET/CT scan Navigated β-probe scan Surface reconstruction Activity map generation Surface extraction Diffusion calculation Rigid registration Comparison

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Diffusion calculation

Methods

PET/CT volume Emission surface CT surface

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Results

PET/CT generated emission surface Navigated β-probe emission surface

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Conclusions

  • PET/CT-generated surfaces present a promising

visualization for surgical planning.

  • The generated PET/CT emission surfaces

correlate well with the ones acquired using the β-probe.

  • This good correlation allows us to confirm this

approach as a valid step toward radio-guided tumor resection and intra-operative nuclear imaging.