Wild Blueberries & Health Research Update WBPANS November 18, - - PowerPoint PPT Presentation

Wild Blueberries & Health

Research Update

WBPANS

November 18, 2016

Fruits, Vegetables and Human Health

Research Publications

From To Publications per Year 1980 1990 0.4 1991 2000 12 2001 2006 68 2007 2012 176 2013 2016 > 558

Plant Foods & Human Health

Berries and especially blueberries lead a major trend in food & health research

Blueberry Health and Nutrition Research

Discussion Topics: A Consumer Focused Plan

• Topline Research Learnings
• Key Change in Thinking
• Marketing Objectives & Strategies
• Target Audience Focus
• Topline Messaging Strategy
• Creative Expression of New Campaign
• Building The Fully Integrated Plan
• Influencer Efforts (PR & Social)
• Key Trade Initiatives
• Online Focus
• 2014 Budget Overview, 2013 Remaining
• 2014 Activity Summary Calendar

Early Blueberry Health Research Blueberry Antioxidants Fight Oxidative Stress

Free Radical Theory of Aging

OXIDATIVE STRESS

• Oxidative damage to DNA, lipids,

protein molecules in the body

• Damage to biomolecules leads to

stress, disease, aging

• Important Balance in the Body:
• Oxidative Stress vs Antioxidant Protection
• Blueberries have a high antioxidant

capacity

OXIDATIVE STRESS, ANTIOXIDANT PROTECTION HEALTH & DISEASE

Wild Blueberries & Antioxidant Capacity

Test tubes

in vitro e.g. ORAC

Populations

Epidemiological

Animals

in vivo

Human trials

Clinical

Evidence for Health Benefits How is it gathered?

Complementary & mechanistic evidence Strong Evidence Evidence from a living system Strong Evidence

BERRIES

Blueberries

Anthocyanins HUMAN HEALTH Anthocyanins are Flavonoids

• Population (epidemiological) studies score anthocyanin

intake based only on strawberry and blueberry intake.

• The world’s strawberry production is 12-times greater

than its blueberry production.

• Blueberries contain > 20-times more anthocyanin than

strawberries.

Where do we get our dietary anthocyanins?

Discussion Topics: A Consumer Focused Plan

• Topline Research Learnings
• Key Change in Thinking
• Marketing Objectives & Strategies
• Target Audience Focus
• Topline Messaging Strategy
• Creative Expression of New Campaign
• Building The Fully Integrated Plan
• Influencer Efforts (PR & Social)
• Key Trade Initiatives
• Online Focus
• 2014 Budget Overview, 2013 Remaining
• 2014 Activity Summary Calendar

Blueberries

• r

Anthocyanins

Population studies

• r

Animal studies

• r

Clinical studies

• r

in vitro studies

Evidence in this review… and

Brain Protection by Blueberries and Anthocyanins

Journal of Gerontology 11 (3): 298–300.

In cognitive and Motor Tests Blueberries protect rats from brain aging Blueberries reverse the effects of brain aging

1999

Anthocyanins and Brain Function during Aging Population Studies

Selected animal studies reporting neuroprotection by blueberries

SEARCH: blueberr* AND brain = 79 publications

• Blueberry diets Increased success of neural grafts (Bickford et al.

2006)

• Blueberries protect against oxidative stress-induced learning

impairment (Duffy et al, 2008)

• Blueberries increased success of neural grafts (McGuire et al.

2007)

• Blueberry supplementation attenuates microglial activation in

intraocular hippocampal grafts to aged hosts (Willis et al. 2010)

• Blueberry diets reduced incidence of experimental autoimmune

encephalomyelitis (Xin et al. 2012)

• Blueberry diets protect the hippocampus after 56Fe irradiation

(Shukitt-Hale et al. 2013) Blueberries fight stresses: Traumatic, oxidative, inflammatory, disease

Journal of Gerontology 11 (3): 298–300.

2010 Apr 14;58(7):3996-4000

* *

Verbal Paired Associate Learning Test

* p<0.05

California Verbal Learning Test

Clinical Study With Children

European Journal of Nutrition, 2016

Discussion Topics: A Consumer Focused Plan

• Topline Research Learnings
• Key Change in Thinking
• Marketing Objectives & Strategies
• Target Audience Focus
• Topline Messaging Strategy
• Creative Expression of New Campaign
• Building The Fully Integrated Plan
• Influencer Efforts (PR & Social)
• Key Trade Initiatives
• Online Focus
• 2014 Budget Overview, 2013 Remaining
• 2014 Activity Summary Calendar

Cardiovascular Protection Anti-Diabetes Protection

Protection against Metabolic Syndrome

Markers of Metabolic Syndrome

• Abdominal obesity
• Elevated plasma lipids
• Elevated blood pressure
• Elevated insulin resistance
• Elevated blood coagulation

factors

• Elevated plasma markers of

inflammation

Metabolic Syndrome

Cardiovascular Disease

High risk for Type 2 Diabetes High risk for Cardiovascular Disease

Blood vessels: More than just plumbing

Vascular Endothelium, Vascular Smooth Muscle

Vascular dysfunction due to hypertension, atherosclerosis and inflammation

• Control of blood pressure
• Control of blood glucose
• Control of “other deliveries”
• Control of blood clotting
• Extensive ‘cross talk’ with blood and vessel wall

Anthocyanins Benefit Human Heart Health Population Studies

Human Clinical Research Target Population = Post-menopausal Women

Journal of Gerontology 11 (3): 298–300. N=66; Age~50 yr; BMI~38; 8 week

First published online July 21, 2010; doi:10.3945/jn.110.124701

21 young healthy men; wild BB powder drink

Acute Effects of Blueberry Intake on Blood Flow in Humans

Journal of Gerontology 11 (3): 298–300.

William T. Cefalu, M.D. Botanical Research Center Pennington Biomedical Research Center Louisiana State University System

Effect of Dose on Blood Total Cholesterol 0.00 0.05 0.10 0.15 0.20 0.25 0.30 0.35 1% 2% 4% Dose ACN (mg C3GE/g feed) 2.20 2.25 2.30 2.35 2.40 2.45 2.50 Total Cholesterol (mmol/L)

Blueberries lower pig plasma cholesterol

BB Anthocyanins

11.7% Blueberry Dose P=0.004

P<0.05

*

*

800 1200 1600 Control Blueberry

WBC/mm2

Blueberry Diet

50μm 50μm

Histological marker of Inflammation

Control Diet

Inflammatory mediators Low fat Diet High fat diet High fat diet + BB

Blueberries and Vision

Human clinical study Animal study Population studies are underway

Discussion Topics: A Consumer Focused Plan

• Topline Research Learnings
• Key Change in Thinking
• Marketing Objectives & Strategies
• Target Audience Focus
• Topline Messaging Strategy
• Creative Expression of New Campaign
• Building The Fully Integrated Plan
• Influencer Efforts (PR & Social)
• Key Trade Initiatives
• Online Focus
• 2014 Budget Overview, 2013 Remaining
• 2014 Activity Summary Calendar

Blueberry Anthocyanins are Absorbed and Metabolized by the Body

Anthocyanins in the Body Recent Findings

Food Anthocyanins Anthocyanin products & metabolites in the body

• Our body retains

anthocyanin metabolites

• Anthocyanins are

found in body tissues

• Anthocyanin

metabolites can enter the brain

Discussion Topics: A Consumer Focused Plan

• Topline Research Learnings
• Key Change in Thinking
• Marketing Objectives & Strategies
• Target Audience Focus
• Topline Messaging Strategy
• Creative Expression of New Campaign
• Building The Fully Integrated Plan
• Influencer Efforts (PR & Social)
• Key Trade Initiatives
• Online Focus
• 2014 Budget Overview, 2013 Remaining
• 2014 Activity Summary Calendar

Emerging Major ‘Take Home Messages ’

• Anthocyanins affect the vascular system to

benefit health in various ways

• Our body’s exposure to anthocyanins is complex

Discussion Topics: A Consumer Focused Plan

• Topline Research Learnings
• Key Change in Thinking
• Marketing Objectives & Strategies
• Target Audience Focus
• Topline Messaging Strategy
• Creative Expression of New Campaign
• Building The Fully Integrated Plan
• Influencer Efforts (PR & Social)
• Key Trade Initiatives
• Online Focus
• 2014 Budget Overview, 2013 Remaining
• 2014 Activity Summary Calendar

Conferences in 2017

Berry Health Benefits Symposium International Conference on Polyphenols and Health 20th Bar Harbour Wild Blueberry Summit Wild Blueberry Health Research Continues to Grow

Clinicaltrials.gov

SEARCH ‘Blueberries’ = 34 clinical trials

• US/CANADA = 71%
• Interventional = 97%
• BB juice or powder = 41%
• BB + 1 ingredient = 9%
• Multi-component

supplements = 50%

• Study size, n = 10-200
• Study end date:

– ‘04-’06 = 4 – ‘07-’09 = 4 – ‘10-’13 = 17 – 2014 & later = 9

Topic

# Anti-ox & anti-inflammation 9 Bioavailability: pharmacology, metabolomics 5 Cancer 3 Cardiovascular: endothelial function, blood

pressure, dyslipidemia, hyperglycemia

10 Gout 1 Metabolic syndrome: Appetite,

hypertension, obesity, diabetes, insulin sensitivity, hyperglycemia

9 Neuroscience: memory, aged-related memory,

cognitive decline, gene expression, headache, migraine

12 Vision 1

Wild Blueberry Health Research Continues to Grow clinicaltrials.gov

Bar Harbor Research Summit Since 1997

Thank You for Your Kind Attention

Wilhelmina (Willy) Kalt

wilhelmina.kalt@agr.gc.ca