with BRCA mutations in Montreal Najlaa Houssaini 1 , Christine - - PowerPoint PPT Presentation

Najlaa Houssaini 1 , Christine Maugard 3, Steven Narod 3, André Robidoux 2 , Parviz Ghadirian 4

McGill University 1 , Medicine, Research Centre (CHUM) 2, Montreal, Familial Breast Cancer Research Unit 3, Women's College Hospital Research Institute, Toronto, Medicine, Université de Montréal, Montréal, Canada4

Case-control study of nutrition and lifestyle among breast cancer women with BRCA mutations in Montreal

Objectives

• The possible role of nutrition and lifestyle in the etiology
• f breast cancer among French Canadian women with

BRCA mutations. Methods

• Nested case-control study
• 44 women with breast cancer compared with 44 women

with no breast cancer.

Risk factors

• Education OR = 7.82, 95% CI :( 1.99-30.69)
• High intake of monounsaturated fatty acid OR = 6.00

Protective factors

• Breast feeding OR = 0.35 95% CI = (0.12-1.06)
• Moderate physical activity OR = 0,28 - 95% IC (0.08-0.95)
• High intake of fruits OR = 0.27; 95% CI :(0.07-1.01)
• Vitamine K OR = 0.17, 95% (0.05-0.61)

Conclusion

Although the sample size of this case-control study was small, we were able to detect certain risk factors among BRCA mutation carriers.