COVID 19 what is it all about ? CORONA VIRUS ELECTRON - - PowerPoint PPT Presentation

what is it all about ?

COVID 19

CORONA VIRUS
 


ELECTRON MICROSCOPE

VIRUS REPLICATING

COVID 19 IN THE LUNGS

• Infects 2 cell types: cilia and mucous cells
• Debris fills airways ….. Cough, fever difficulty

breathing

• Many develop pneumonia

CILIA CELLS SWEEP UPWARDS

BOTH CELL TYPES ARE TARGETS OF 
 COVID 19

IMMUNE REACTION TO VIRUSES

• Intra-cellular parasite
• Once inside viral DNA or RNA “edited” into DNA of host cell and cell

stops doing its’ work.

• Replication begins and antigens appear on the membrane activating

innate immune system

• Interferon and NK cell activation
• IL 1B and IL18
• Interferon A and B produced by macrophages-monocytes
• CD4 and CD8 lymphocytes and NK cells interferon gamma
• Then adaptive response is CD8, phagocytosis and complement

IMMUNE RESPONSE IS ALTERED

• Normal immune/inflammatory process confined to infected areas.
• Immune reaction spreads to healthy tissue and damages increases
• When this happens, 3rd stage and causes respiratory failure and worsening

pneumonia

• Same as SARS …. Holes in the lung due to hyperactive immune response
• Increase permeability of alveoli – poor exchange and fluid accumulation

Cytokine storm causes total body inflammation,- multi organ failure

WHAT IS COVID-19

Family of RNA viruses (DNA, RNA & retroviruses)

Only 7 affect humans Most are mild Three types - sickness and death in humans

• 1. SARS 2002-3 …. 10% mortality (controlled 2003)
• 2. MERS 10 years later …. 34% mortality (2,465 since 2012)
• 3. COVID-19 … 0.5-20% mortality

Full genome published January 29, 2020 by Chinese (70% similarity to SARS)

SEASONAL FLU

• WHO: 3-5 million cases of severe illness and about 389 000 deaths from

respiratory causes are associated with influenza each year on average (range 294 000 - 518 000)

• Most countries, including the United States, the incidence of seasonal

flu and flu-related deaths in adults are not reportable illnesses

• Consequently, mortality is estimated by using statistical models
• Whats the true infection and mortality rates ?

CORONA VIRUSES

• Illness ranging from the common cold to severe illness
• Middle East Respiratory Syndrom (MERS-CoV)
• Severe Acute Respiratory Syndrome (SARS-CoV)
• Novel coronavirus (COVID-19) a “new” strain that has not been

previously identified in humans.

• Zoonotic virus … common animals and birds

CHARACTERISTICS

“COVID -19” = “coronavirus disease 2019” by WHO

Symptoms 98% 1st few days after exposure

• Fever (38-39 C)
• Cough (76%)
• Muscle aches & fatigue (44%)
• Shortness of breath (55%)
• ARDS (29%)
• Male predominance 78%

COVID 19

• Official story: bats to humans or through pangolins

(intermediate host)

• Now human to human
• 81% of cases symptoms are mild (lungs)
• 14% severely ill
• 4.7% critically ill
• Fatality rate 3.4 % (0.1-20%)
• 100% of fatalities in the critical condition
• Age over 65 years most fatalities

COVID 19 IN THE BODY

Protein spikes on surface connect with receptor of cell then insert genetic material Host cells stops working - produces new viruses (replication) COVID 19 uses same receptors as SARS: Lungs & Small Intestines Same as SARS – 3 phases 1. Viral Replication

• 2. Hyperreactivity of immune system

3. Pulmonary (lung) destruction

TRANSMISSION

Transmission respiratory droplets… Some clusters of confirmed had not been in contact with anyone ????

• Once exposed …. 7 days later - infectious to others
• Onset of symptom 5.2 days (4.1-7) …. Longest 12.5 days
• First outbreak in US….in Kirkland near Seattle …. 1 of 5 cities in US

with 5G (only 5 cities in US)

• Evergreen hospital …. Wifi measurments highest ever recorded …..

mortality 60%

DIAGNOSIS

• PCR is gold standard
• Fever and dry cough
• If 1st abdominal cramping and bloating first then fever and cough –

more serious

• LAB: CBC…If low WBC and low lymphocytes probably - Covid 19
• Cough…X-RAY …. Infiltrates
• CT – ground glass consolidation almost always bilateral

GOVERNMENT RECOMMENDATIONS

Soap and water more effective than 60% alcohol hand sanitizer

HYPOCHLOROUS ACID

• Hypochlorous acid was discovered in 1834 by the French

chemist Antoine Jérôme Balard (1802–1876)

• ,Hypochlorous acid is generated in

activated neutrophils by myeloperoxidase-mediated peroxidation of chloride ions, and contributes to the destruction of bacteria.

• E. coli exposed to hypochlorous acid lose viability in less than 0.1

seconds due to inactivation of many vital systems caused 100% growth inhibition in 5 minutes.

• Same effect with viruses.

HYPOCHLOROUS ACID (HOCL)

MERS was sprayed on computer and desk

• Sprayed 60% alcohol-PCR +
• HOCl 100% effective PCR -

Microbicidal effect various

• rganisms

Recommended use in hospitals and food service – restaurants

COVID-19 Has been effective against all corona viruses reasonable that it is effective with CoV-19

2 MORE STUDIES

Used with wound disinfection and area decontamination Used HOCl with human coronanvirus 0C43 (almost same as CoV-19)

• Sprayed and tested after 10

minutes

• 99.999% effective

PROPOLIS

• Bees combine sap with their own discharges & beeswax
• Sticky, greenish-brown - used to coat their hives
• Greeks - treated abscesses
• Assyrians - on wounds and tumors to fight infection and

promote healing

• Egyptians used it to embalm mummies

PROPOLIS SPRAY TREATMENT

PREVENT COVID-19 FROM ENTERING THE LUNGS

• HOCl acid and propolis
• Alternate at least every hour after onset of symptoms
• Propolis only in the throat
• HOCl eyes, nose and throat
• When symptoms progressed to a dry cough – lungs
• Still have 72% in the throat - continue growing

INITIAL TREATMENT

• Virus survive 72 hours on table …. (after sneezing)
• Inside body … surface of throat, nose (sore throat & fever) for 5

days

• 5 days from 1st onset of symptoms treat locally
• Treat with a spray … hypochlorous acid and propolis sprayed

into eyes, throat and nose

• Propolis enhances immunity….a few days later asymptomatic

(HOCl + propolis)

CURRENTLY “NO TREATMENT”

“No treatment” = No drugs Unlike antibiotics, antivirals do not “kill” viruses because they are not alive Acyclovir is one example of an anti-viral drug and it is useful for only herpes simplex and varicella It is a nucleoside analogue that inhibits replication so slows down and aborts infections. Influenza drugs stop the virus from entering the cell blocking ion channels Only “treatment” is supportive care

TREATING A POSSIBLY INFECTED PERSON

• Vitamin C dose-dependent inhibition of NLRP3 inflammsomes decreases

IL-1B secretion

• Vitamin C IV 10—20 grams for 3 day very high remission rate

(Zhongnan Hosp)

• Alinia 1000mgs twice a day for 10 days
• Chloroquine phosphate (Plaquenil): 500 mg for 10 days.
• Artesunate 250 mg IV daiy for 10 days OR artemisia annua tincture in milder

cases

TREATMENT

• No vaccine
• Chloroquine PO4 (100%

effective in-vitro)

• Remdesivir

(not available)

• Nitazoxanide (Alinia)

anti-parasitic also effective with “flu”

CHLOROQUINE

• Chloroquine phosphate was introduced in 1940’s - treatment of malaria
• Shown to have apparent efficacy and acceptable safety against COVID-19

associated pneumonia in multicenter clinical trials conducted in China.

• The drug is recommended to be included in the next version of the Guidelines

for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19

• Antiviral activities by increasing endosomal pH required for virus/cell fusion, as

well as interfering with the glycosylation of cellular receptors of SARS-CoV

• 100 patients have demonstrated that chloroquine phosphate promotes a virus

negative conversion, and shortening the disease course.

EFFECTIVE TREATMENT PUB MARCH 13, 2020

• Spanish and Italian researchers &

Stanford U and NAS

• Results: 100% cured (PCR neg)

within 6 days

• 40 patients …. 20/20 cured
• Used since 1945 malaria,

autoimmune, etc

• Few days later….EU made it

unavailable

NITAZOXANIDE (NTZ)

• Broad-spectrum anti-

parasitic, ant bacteria, and viruses.

• Inhibit the replication of

several RNA and DNA viruses

• Phase 3 clinical trials
• Effective with MERS, SARS

and influenza

VITAMIN C A WELL KNOWN ANTI-VIRAL

• Polio
• Measles
• Mumps
• Rubella
• Influenza
• Hepatitis A, B, C
• Varicella Zoster
• Herpes I and II
• HIV
• Coronavirus

CSS SYNDROME

• Chronic Subclinical Scurvy (the CSS Syndrome) is our most

widespread disease (Stone, 1972).

• 45 mg of ascorbate will prevent the appearance of the terminal

symptoms of the disease

• To correct Chronic Subclinical Scurvy requires at least 10 grams of

ascorbate a day depending upon the incident stresses (Stone, 1977).

• Under heavy stresses the daily ascorbate requirement may be 200

grams or 300 grams to keep ahead of the CSS Syndrome.

• The long term biochemical results of Chronic Subclinical Scurvy set

the stage for the development of the serious medical problems of later life; the heart attacks, the cancer, the collagen diseases and many more.

• Preliminary clinical tests indicate that mega levels of ascorbate are

useful in the prevention and treatment of viiral infections, cancer (Stone, 1974, 1976), heart disease, and many others (Stone 1972). In the case of viral diseases (Pauling, 1978, Stone, 1972), research of the past 30 years indicates that no one should succumb to a viral infection any more.

SIRS

• Systemic Inflammatory Response Syndrome (SIRS) is a term

characterizing an inflammatory syndrome caused by infectious or traumatic causes

• SIRS is different than sepsis in that in sepsis an active infection is found
• These patients may progress to acute kidney or lung failure, shock, and

multiple organ dysfunction syndrome.

• Septic shock refers to conditions in which the patient has a systolic

blood pressure of less than 90 mmHg despite sufficient fluid resuscitation and administration of vasopressors/inotropes.

TREATMENT OF SIRS

• To date, the only drug to have elicited an effect on SIRS in Phase III

double-blind, placebo-controlled trials has been Xigris (activated protein C (APC))

• The beneficial effects of Xigris in SIRS = its ability to prevent the

endothelial dysfunction associated with suppression of pro- inflammatory chemokines prevention of endothelial cell apoptosis and increased endothelial fibrinolytic activity.

• Some of the protective activities of Xigris have been ascribed to its

ability to suppress NF-kB activation in endothelial cells

VITAMIN-C DOES IT ALL

• AA exerts its effect through endothelial cell apoptosis, upregulation of adhesion

molecules, and the procoagulant state

• AA has been demonstrated to reduce endothelial cell expression of the adhesion

molecule ICAM-1 in response to TNF-alpha in vitro in human umbilical vein endothelial (HUVEC) cells

• Other endothelial effects of AA include suppression of tissue factor upregulation

in response to inflammatory stimuli, and prevents the hypercoaguable state.

• Given the importance of NF-kappa B signaling in coordinating endothelial

inflammatory changes , it is important to note that AA at pharmacologically blocks

• f NF-kappa B
• Mechanistically, several pathways of inhibition have been identified including

reduction of i-kappa B phosphorylation and subsequent degradation, and suppression of activation of the upstream p38 MAPK pathway.

EARLY CHINESE DATA


 ORTHOMOLECULAR MEDICINE NEWS SERVICE, JAN 26, 2020
 VITAMIN C PROTECTS AGAINST CORONAVIRUS


BY ANDREW W. SAUL, EDITOR


• (OMNS January 26, 2020) The coronavirus pandemic can be dramatically slowed, or stopped,

with the immediate widespread use of high doses of vitamin C. Physicians have demonstrated the powerful antiviral action of vitamin C for decades. There has been a lack of media coverage of this effective and successful approach against viruses in general, and coronavirus in particular.

• It is very important to maximize the body's anti-oxidative capacity and natural immunity to

prevent and minimize symptoms when a virus attacks the human body. The host environment is crucial. Preventing is obviously easier than treating severe illness. But treat serious illness seriously. Do not hesitate to seek medical attention. It is not an either-or

• choice. Vitamin C can be used right along with medicines when they are indicated.

"I have not seen any flu yet that was not cured or markedly ameliorated by massive doses of vitamin C."
 
 (Robert F. Cathcart, MD)


 
 VITAMIN C INFUSION FOR THE TREATMENT OF SEVERE 2019-NCOV INFECTED PNEUMONIA


• Cytokine surge caused by sepsis is activated, and neutrophils in the

lungs accumulate in the lungs, destroying alveolar capillaries.

• Early clinical studies have shown that vitamin C can effectively

prevent this process.

• Vitamin C can helps to eliminate alveolar fluid by preventing the

activation and accumulation of neutrophils, and reducing alveolar epithelial water channel damage

• Vitamin C can prevent the formation of neutrophil extracellular

traps, which is a biological event of vascular injury caused by neutrophil activation..

ANTI-INFLAMMATORY

• Decreases NF-kappaB activity
• Decreases LPS mediated inflammatory response
• Decreases IL-1alpha
• Decreases IL-2
• Decreases IL-8
• Decreases TNF-alpha
• Decreases Epidermal Growth Factor (EGF)
• Decreases Monocyte Chemoattractant Protein (MCP)
• Decreases CRP

IMMUNO-MODULATION

• Blocks NF-kappaB activation
• Enhances Tcell proliferation
• Enhances Tcell maturation
• Increases NK cell proliferation
• Increases Dendritic cell activity
• Increases IL-12 levels
• Promote Tcell Th1 differentiation
• Increases CD8 effector Tcells
• Increases effector memory Tcells
• Reduces Neutrophil Extracellular

Traps (NETs)

• Improves the efficacy of PD-L1

therapies

• Suppresses IL-6 in the TME
• Reduces TGF-ß
• Reduces Macrophage

Inflammatory Protein (MIP)

• Reduces TARC (thymus and

activation-regulated chemokine)

VITAMIN C (ANTI-VIRAL)

• Antioxidant
• Direct virus cytotoxicity
• Inactivated virus
• Inhibits viral (DNA) activity
• Inactivates viral (RNA) activity
• Suppresses viral replication
• Inhibits viral assembly
• Decreases viral shedding
• Increases innate immunity
• Increases T lymphocyte activation
• Enhances chemotaxis of

neutrophils, monocytes...

• Stimulates phagocytosis and

antigen presentation

• Increases IFN-alpha/beta
• Increases NK cell activity
• Protects lymphocytes and

neutrophils against oxidative damage

• Increases lymphocyte production
• Increases neutrophil function
• Increased dendritic cell activity
• Increases serum Immunoglobulin

production

syndrome. hours: HSV, CMV, and parainfluenza. RSV though not as successful, had

VITAMIN C AND COVID-19

• SARS-CoV and MERS-CoV
• Inflammatory Storm: IL1B, IL6, IL12,

IL15, IL17,TNFα. IFNγ, IP10 and MCP1

• Increased IL-10
• Vitamin C depletion
• Decreased absolute Lymphocytes
• Immunoparalysis
• Pulmonary inflammation
• Downregulation of neutrophil

function

• Downregulation of Monocyte

function

• Pulmonary damage
• Decreased apoptosis cell clearance
• ARDS
• Septic Shock
• Multi-organ failure
• Death

CHINA IS CONDUCTING A CLINICAL TRIAL OF 24 G/DAY OF INTRAVENOUS VITAMIN C FOR CORONAVIRUS PATIENTS 


Inclusion Criteria:

• ≥ 18 years old;
• Diagnosed as serious or critical SARI (according to the 4th version of Diagnosis

and Clinical management of 2019-nCoV infected pneumonia);

• Being treated in the ICU.
• They will receive it for 7 days straight at Zhongnan Hospital of Wuhan University.

Zhiyong Peng, MD is chief physician and professor at the hospital, at ground zero for coronavirus. This study was filed and announced today. https://clinicaltrials.gov/ct2/show/NCT04264533

HOSPITAL-BASED INTRAVENOUS VITAMIN C TREATMENT
 FOR CORONAVIRUS AND RELATED ILLNESSES
 


BY ANDREW W. SAUL AND ATSUO YANAGISAWA, MD, PHD


• The Japanese College of Intravenous Therapy (JCIT) recommends

intravenous vitamin C (IVC) 12.5/25g (12,500 - 25,000 mg) for acute viral infections (influenza, herpes zoster, common cold, rubella, mumps, etc.) and virus mimetic infections (idiopathic sudden hearing loss, Bell's palsy).

• In adults, IVC 12.5g is given for early stage illness with mild

symptoms, and IVC 25g for moderate to severe symptoms. IVC is usually administered once or twice a day for 2-5 continuous days, along with or without general treatments for viral infections.

JCIT

• Patients with acute viral infections show a depletion of vitamin C

and increasing free radicals and cellular dysfunction.

• Such patients should be treated with vitamin C, oral or IV, for

neutralizing free radicals throughout the body and inside cells, maintaining physiological functions, and enhancing natural healing.

• If patients progress to sepsis, vitamin C should be added

intravenously as soon as possible along with conventional therapy for sepsis. Research and experience has shown that a therapeutic goal of reaching a peak-plasma concentration of ~20 mM (350- 400 mg/dL) is most

• efficacious. (No increased toxicity for posoxidant IVC plasma vitamin C

levels up to 780 mg/dL has been observed.) . .

DR RICHARD CHENG IN SHANGHAI

• “Early and sufficiently large doses of intravenous vitamin C are
• critical. Vitamin C is not only a prototypical antioxidant, but also

involved in virus killing and prevention of viral replication.

• The significance of large dose intravenous vitamin C is not just at

antiviral level. It is acute respiratory distress syndrome (ARDS) that kills most people from coronaviral pandemics (SARS, MERS and now NCP). ARDS is a common final pathway leading to death. “We therefore call for a worldwide discussion and debate on this topic.”

• “At my hospital in Daegu, South Korea, all inpatients and all staff

members have been using vitamin C orally since last week. Some people this week had a mild fever, headaches and coughs, and those who had symptoms got 30,000 mg intravenous vitamin C. Some people got better after about two days, and most had symptoms go away after one injection.” (Hyoungjoo Shin, M.D.)

• “We need to broadcast a message worldwide very quickly: Vitamin C

(small or large dose) does no harm to people and is the one of the few, if not the only, agent that has a chance to prevent us from getting, and can treat, COVID-19 infection. When can we, medical doctors and scientists, put patients’ lives first?” (Richard Z. Cheng, MD, PhD, International Vitamin C China Epidemic Medical Support Team Leader).

“On the afternoon of February 20, 2020, another 4 patients with severe new coronaviral pneumonia recovered from the C10 West Ward of Tongji Hospital. In the past 8 patients have been discharged from hospital. . . [H]igh- dose vitamin C achieved good results in clinical applications. [E]arly application of large doses of vitamin C can have a strong antioxidant effect, reduce inflammatory responses, and improve endothelial function. [H]gh-dose vitamin C can not only improve antiviral levels, but more importantly, can prevent and treat acute lung injury (ALI) and acute respiratory distress (ARDS).”

HYDROCORTISONE, VITAMIN C AND THIAMINE FOR THE

TREATMENT OF SEPSIS AND SEPTIC SHOCK FOLLOWING CARDIAC SURGERY


MAHESH BALAKRISHNAN, HEMANG GANDHI, KOMAL SHAH, HIMANI PANDYA, RAMESH PATEL, SUNNY KESHWANI, AND NIKHIL YADAV


• About 24 patients with septic shock were randomised into Group 1

(receiving matching placebo per day for 4 days) and Group 2 (receiving 6 g vitamin C, 400 mg thiamine and 200 mg hydrocortisone per day for 4 days). Conclusion:

• Combination of vitamin C, thiamine and hydrocortisone reduces

vasopressor requirement in adult cardiac surgical patients with septic shock.

VITAMIN C REDUCES MORTALITY FROM SEPSIS WITH ARDS IN CITRIS-ALI RANDOMIZED TRIAL … ? 


PULM CNN OCT 2019


• Authors randomized 167 adults at 7 centers diagnosed with sepsis and

acute respiratory distress syndrome (ARDS) to receive ascorbic acid infusion (50 mg/kg) or placebo every 6 hours for 4 days. Patients had to develop ARDS within 24 hours of ICU admission. Patients were similarly vitamin C-deficient between groups

• There was a remarkable reduction in 28-day all-cause mortality rate

among the patients receiving vitamin C: 29.8% in the treatment group and 46.3% in the placebo group, which was statistically significant There were also improvements in ICU-free days and days out of the hospital at day 60.

NEWS OF VITAMIN C RESEARCH FOR COVID-19 
 ACTIVELY SUPPRESSED


• Anyone saying that vitamin therapy can stop coronavirus is already being labeled

as “promoting false information” and promulgating “fake news.” Even the sharing of verifiable news, and direct quotes from credentialed medical professionals, is being restricted or blocked on social media

• World Health Organization (WHO) has met with Google and Facebook and
• ther media giants to stop the spread of what they declare to be wrong
• information. https://www.cnbc.com/amp/2020/02/14/facebook-google-amazon-

met-with-who-to-talk-coronavirus-misinformation.html? __twitter_impression=true

ANTI-FURINS 
 PLAN B

• Furins are proteins in cell wall….
• Covid 19 is pre-activated
• Covid 19 is activated by furins
• Without furins, cannot enter the

cell…triggers cytokine storm

• Anti-furin strategy known with

HIV

• Herb: Andrographic paniculata

blocks the activation leading to cytokine storm.

• Very bitter herb … andrographis

1 dropper 4-6/day…1 hourly if symptoms

VIROPORINS AND NLRP3 INFLAMMASOMES

• Viroporins form lipid ion

channels - allow newly replicated viruses to escape

• Allow calcium in initiates the

cascade of cytokines -trigger activation of NLRP3 and then IL-1B resulting in cytokine storm

• Activates the NO enzymes

leading to peroxynitrates & OH

• WiFi & radiowaves also opens

“voltage gated calcium channels” VGCC

• Therefore WIFI hygiene is

essential.

• Wear protective clothing and

turn off WiFi

VITAMIN C INHIBITS THE ACTIVATION OF THE NLRP3 INFLAMMASOME BY SCAVENGING MITOCHONDRIAL
 ROS


XUESONG SANG# , HONGBIN WANG# , YIHUI CHEN, QIUHONG GUO, AILING LU, XIAOLI ZHU, GUANGXUN MENG*

DOI 10.1515/infl-2016-0001 Received November 10, 2015; accepted January 10, 2016

Abstract: Inflammasomes are intracellular protein complexes that mediate maturation and

secretion of the pro-inflammatory cytokines IL-1β and IL-18. Inflammasomes have been connected with various diseases, therefore the regulation of inflammasome activation is important for the development of novel therapies for many inflammatory syndromes.

Vitamin C is an essential nutrient and has regulatory effects on immune cells.

Here we report that vitamin C has an inhibitory effect on the activation of the NLRP3 inflammasome in vitro and in vivo. Mechanistically, this inhibition is through scavenging mitochondrial ROS but not through NF-κB inhibition. Moreover, specificity tests show that the AIM2 inflammasome and the NLRC4 inflammasome can also be inhibited by vitamin C. Our results have thus identified a new inflammasome regulator and provide therapeutic potential for inflammasome-associated diseases.

• Melatonin is the most potent

inhibitor of the inflammasomes.

• Reduces IL-1B secretion and

attenuates inflammasome-associated vascular disorders by improving endothelial leakage and suppressing NLRP3 inflammasomes.

• If a patient (any age) has adequate

melatonin, the infectiousness of Covid 19 will be greatly reduced.

• Melatonin is reason why children < 9

years old seldom exhibit severe symptoms even when infected with SARS-Co-2

• Melatonin inhibits NLRP3 and

prevents severe myocardial damage

• Volt et al showed that acute

administration of melatonin could counteract severe inflammatory response .

MELATONIN BY AGE

PREGNANCY & MELATONIN

• None of the pregnant mothers infect by Covid 19 admitted

to Zhongnan Hospital in Wuhan developed severe pneumonia or died, nor did their babies.

• Melatonin secretion in the 3rd trimester = 2x 1st trimester
• 1st trimester melatonin 2x normal population

WiFi = most potent inhibitor melatonin production

HUMMING AND NITRIC OXIDE

EMF & VGCC

• 23 studies VGCC = direct targets

low and microwave, non-thermal – animal calcium channel blockers

• 1 million Ca2+ per second enter
• Ca2+/calmodulin stimulation of

nitric oxide synthesis.

• Nitric oxide+superoxide -

peroxynitrite-oxidative stress pathway – OH radical

• Upper inner quadrant breast ca
• Renal cell carcinoma
• 10% decrease bone density femur

MICROWAVE –
 PHONES, BLUE TOOTH, ALL “SMART” DEVICES,

OVEN, ROUTERS, WIRELESS MOUSE


• VGCC activated by EMF
• 1 million calcium ions stream through each second.
• Stimulates NO combines with superoxide to produce peroxynitrates then

OH

• DNA breaks, mitochondria & nucleus….decimates proteins and destroys

membranes

• Highest concentration …. Retina …. Brain … heart nerve tissues
• Sperm count decrease 50%...ovaries, etc
• VGCC release neurotransmitters so depression, etc
• More dangerous than x-rays…gamma rays at 35,000 feet…

MOLECULAR HYDROGEN H2

• We produce about 10 liters a day
• Smallest molecule in the universe
• Non polar easily penetrates all cells
• H2 + OH- = H2O WATER …. No intermediates
• Selective anti-oxidant …. Certain quantity of free radicals required for life
• Gamma rays at 35,000 feet produces free radicals …decrease 80%
• Tablet in water (not cold) dissolve with cap and then drink quickly – 2 hours
• Use after exercise and won’t block any ROS that would benefit from exercise (selective)
• 1st study in 2007 (Nagoya University)
• Tyler Le Baron over 45 publications Molecular Hydrogen Institute
• Modifies lipid peroxidation, protein phosphorylations, and gene expressions, resulting in

anti-inflammatory, anti-allergy, and anti-aging benefits

H2 SELECTIVE 
 ANTI-OXIDANT

• Significant increase in superoxide

dismutase and pAKT, a cell survival signaling molecule.

• Erythroid 2-related factor 2 an

important regulator of oxyradical homeostasis, as well as it supports the functional integrity of cells, particularly under conditions of

• xidative stress.
• Activation of nuclear factor

erythroid 2-related factor 2 pathway that promotes innate antioxidants and reduction of apoptosis, as well as inflammation.

ACE INHIBITORS INCREASE VIRULENCE OF COVID-19

• Covid-19 infects host cells by binding

with ACE-2 receptors

• ACE inhibitors increase the

expression of ACE-2 receptors Effect of

Angiotensin-Converting Enzyme Inhibition and Angiotensin II Receptor Blockers on Cardiac Angiotensin-Converting Enzyme 2 Carlos M. Ferrario et al16 May 2005

• Using ace inhibitors either through

medications or supplements may increase the risk of fatal complications with Covid 19 The Lancet

• Taking ACE inhibitors facilitates

entry of virus into the lungs

VITAMIN D

All Coronavirus attach to ACE2 enzyme in human cells 
 Vitamin D reduces ACE2 enzyme 
 All previous human Coronavirus successfully treated with Vitamin D 


Adequate vitamin D levels in the blood prevents attachment the

• f COVID-19

ANGIOTENSIN-CONVERTING ENZYME 2 IS A FUNCTIONAL RECEPTOR FOR THE SARS CORONAVIRUS

Vitamin D alleviates lipopolysaccharide-induced acute lung injury via regulation of the renin-angiotensin system - 2017 From Discussion: "The mRNA expression levels of ACE and ACE2 in NT, LPS and LPS + calcitriol-treated lung tissues were also determined, and the results demonstrated that LPS increased ACE expression and decreased ACE2 levels compared with the NT group"

Calcitriol treatment inhibited the effects of LPS on ACE and ACE2 mRNA expression

VITAMIN A & IMMUNITY TO VIRAL, BACTERIAL AND PROTOZOAN INFECTIONS.


PROC NUTR SOC. 1999 AUG;58(3):719-27.
 SEMBA RD1.

Three active forms retinol, retinal, and retinoic acid. Vitamin A =“anti-infective” -- many of the body's defenses against infection depend on vitamin A. Vitamin A plays a major role in immunity, including expression of mucins and keratins, lymphopoiesis, apoptosis, cytokine expression, production of antibody, and the function of neutrophils, NK cells, monocytes or macrophages, T lymphocytes and B lymphocytes. Recent clinical trials - vitamin A supplementation reduces morbidity and mortality in different infectious diseases, such as measles, diarrheal infections, measles-related pneumonia, HIV and malaria. The mechanism inhibit measles replication is upregulating the innate immune response in uninfected bystander cells, making them refractory to productive infection during subsequent rounds of viral replication Vitamin A supplementation - protection against the complications of life-threatening infections, including malaria, lung diseases, and HIV. Protective against progressing to pneumonia with measles and other viruses in children of underdeveloped countries.

ZINC

Increasing intracellular zinc impairs RNA viral replication “Zn(2+) was found to block the initiation step of EAV RNA synthesis, whereas in the case of the SARS-CoV RdRp elongation was inhibited and template binding reduced”

ZINC

After age 40, the thymus gland begins to shrink with low of thymulin. Stimulates the production

• f T cells, necessary to

protect from cancer and viral (and other) infections. > 65 years -15 mg zinc per day restoration of youthful levels of thymulin and T cell activity

CHLOROQUINE AND ZINC

• Published in PLoS ONE, “Chloroquine is a Zinc Ionophore,” shows how

chloroquine drives zinc into cancer cells, causing apoptosis (cell death). Chloroquine

enhanced zinc uptake by A2780 cells in a concentration-dependent manner, as assayed using a fluorescent zinc probe. This enhancement was attenuated by TPEN, a high affinity metal-binding compound, indicating the specificity of the zinc uptake.

• And since zinc prevents corona virus from replicating as stated in PLoS journal

“Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture.”

“It is very likely, in our estimation, that most of the people dying from coronavirus are zinc deficient. ”

FLAVONOIDS

• Natural substances with

variable phenolic structures, are found in fruits, vegetables, grains, bark, roots, stems, flowers, tea and wine.

• Over 5000 naturally
• ccurring flavonoids
• Potent antioxidants, anti-

inflammatory, antiallergic, antihemorrhagic, antimutagenic, antineoplastic, and hepatoprotective activities

• Potent inhibitors for several

enzymes, such as xanthine

• xidase (XO), cyclo-
• xygenase (COX),

lipoxygenase and phosphoinositide 3-kinase

• Anti bacterial and anti viral

FLAVONOID-MEDIATED INHIBITION OF SARS CORONAVIRUS 3C-LIKE PROTEASE EXPRESSED IN PICHIA PASTORIS

Conclusions

• An important goal of the present study was to understand the

inhibition by seven flavonoid compounds belonging to four groups of flavonoids (flavonol, flavanonol, isoflavone, and flavan-3-ol) against 3CLpro of SARS-CoV.

• Quercetin, epigallocatechin gallate and gallocatechin gallate

(GCG) displayed good inhibition toward 3CL(pro) with IC(50) values of 73, 73 and 47 μM, respectively. GCG was the best inhibitor against 3CLpro by an in-vitro assay.

GCG = GREEN TEA

MELATONIN AND VITAMIN C
 IF SICK

Melatonin

• 60 mg transdermal cream in AM and around 2-3:00 PM
• 30 mg 2 hours after eating and at bedtime
• No melatonin before 3:00 PM if diabetic

Vitamin C

• 1 gram every 15-30 minutes or every hour depending on how sick
• An almost unlimited tolerance if sick
• IV is better

KLINGHARDT RECOMMENDS

PREVENTION

• Vitamin C: 8,000-15,000 mg (or more) daily, in divided doses.
• Vitamin D3: 20,000-30,000 International Units daily (>70) check levels 3 weeks
• Magnesium: 400 mg 2-3 daily (in citrate, malate, chelate, or chloride form)
• Zinc: Load with 200 mg day 1 then 90 mg daily (30 mg 3 times a day)
• Selenium: 400 mcg (micrograms) daily – unless at risk for infection or +
• Manganese 8-12 mg 2 times per day
• Vitamin A 50,000 iu daily (check levels in 1 month)
• Use HOCl and Propolis
• Molecular hydrogen every 2-3 hours while awake
• Drink fresh brewed, organic green tea (several cups/day)
• Drink 3 liters of fluid (water or fresh vegetable juice) per day

CONSIDER AS PREVENTION IF AT RISK

• Chloroquine phosphate 500 mg once (or twice) a day
• Nitozoxanide (Alinia) 1000 mg once or twice a day
• Vitamin C 25 grams IV 3 times a week followed by ALA 300 mg/B
• Ozone (10 pass) twice per week
• Have immune system evaluated (NK cell function, lymphocyte subset) and

treated appropriately

LIFESTYLE

• Sleep by 9:00 PM latest – use sleep hygiene
• Enema (salt water) in AM if you have < 3 bowel movements per day
• Meditate, read and exercise in AM before day starts
• Eat no more than twice per day with 18 hours between last and first meal
• Stop eating 4-5 hours before sleep
• Eat organic, whole foods with 70% (minimum) uncooked
• Eat 40% healthy fats (seeds, nuts, avocado, coconut oil)
• HCl acid 15 minutes before meals if over 40 years of age (or chronically ill)
• Digestive enzymes after each meal
• Probiotics twice per day
• Use a BEMER twice per day (minimum)

EMF HYGIENE

• Change to wired connections and stop Wi-Fi
• Ethernet for computer
• Talk on speaker or use wired earplugs
• Turn phone off when not using
• Protective clothing, including gloves for handling phone
• Faraday cage bed if you live in an apartment building
• Stand on the earth barefoot 40-60 minutes per day and visit parks daily (> 1 hour)

IF SICK AND PCR+ COVID 19

• Vitamin C 50 grams IV daily for 7-10 days then taper (pure vitamin C)
• ALA/B IV after vitamin C
• Artesunate 10 mg/kg IV twice per week
• Chloroquine phosphate 500 mg twice a day for 10 days
• Alinia 1000 mg twice a day for 10 days
• Supplements (no selenium)
• Lifestyle
• Oral or IV hydration daily
• EMF hygiene