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Deceased Donor Transplants Patients transplanted between 01/01/2010 and 12/31/2010

UCSF Region US

PAH

8.7 5.8 5.5

CF

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65.2 47.5 45.8

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% of Transplants Recipient Age 1985-1994 (N=4,740) 1995-2004 (N=16,277) 2005-6/2012 (N=22,406)

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(years) 1985-1994 = 47 1995-2004 = 51 2005-6/2012 = 55

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Mahidhara R. J Thorac Cardiovasc Surg 2008;135:412-420

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DIAGNOSIS SLT (N = 12,339) BLT (N = 18,334) TOTAL (N = 30,673) COPD/Emphysema 5,769 ( 46.8% ) 4,839 ( 26.4% ) 10,608 ( 34.6% ) Idiopathic Pulmonary Fibrosis 3,995 ( 32.4% ) 2,938 ( 16.0% ) 6,933 ( 22.6% ) Cystic Fibrosis 214 ( 1.7% ) 4,941 ( 26.9% ) 5,155 ( 16.8% ) Alpha-1 728 ( 5.9% ) 1,225 ( 6.7% ) 1,953 ( 6.4% ) Idiopathic Pulmonary Arterial Hypertension 78 ( 0.6% ) 894 ( 4.9% ) 972 ( 3.2% ) Pulmonary Fibrosis, Other 424 ( 3.4% ) 537 ( 2.9% ) 961 ( 3.1% ) Bronchiectasis 50 ( 0.4% ) 815 ( 4.4% ) 865 ( 2.8% ) Sarcoidosis 236 ( 1.9% ) 547 ( 3.0% ) 783 ( 2.6% ) Re-Transplant: Obliterative Bronchiolitis 253 ( 2.1% ) 219 ( 1.2% ) 472 ( 1.5% ) Connective Tissue Disease 127 ( 1.0% ) 232 ( 1.3% ) 359 ( 1.2% ) Obliterative Bronchiolitis (Not Re- Transplant) 80 ( 0.6% ) 237 ( 1.3% ) 317 ( 1.0% ) LAM 101 ( 0.8% ) 207 ( 1.1% ) 308 ( 1.0% ) Re-Transplant: Not Obliterative Bronchiolitis 127 ( 1.0% ) 162 ( 0.9% ) 289 ( 0.9% ) Congenital Heart Disease 43 ( 0.3% ) 224 ( 1.2% ) 267 ( 0.9% ) Cancer 6 ( 0.0% ) 26 ( 0.1% ) 32 ( 0.1% ) Other 108 ( 0.9% ) 291 ( 1.6% ) 399 ( 1.3% )

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1988-1994: 1/2-life = 4.7 Years; Conditional 1/2-life = 7.9 Years 1995-1999: 1/2-life = 4.8 Years; Conditional 1/2-life = 7.5 Years 2000-6/2009: 1/2-life = 5.9 Years; Conditional 1/2-life = 8.0 Years N at risk =552 N at risk = 702 N at risk = 841

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