Selection and haplotypes EHH statistics Anders Albrechtsen - PowerPoint PPT Presentation

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Selection and haplotypes EHH statistics Anders Albrechtsen Haplotypes Signature of selection Mutation enters the population Mutation increases in frequency due to positive selection Increases LD Affects the variability

Selection and haplotypes EHH statistics Anders Albrechtsen
Haplotypes Signature of selection • Mutation enters the population • Mutation increases in frequency due to positive selection • Increases LD • Affects the variability • Increases haplotype similarity • Increases differences with other populations in the whole region
Haplotypes EHH - Extended Haplotype Homozygosity What is EHH? Extended haplotype homozygosity (EHH): EHH at distance x from the core region is the probability that two randomly chosen chromosomes carry a tested core haplotype are homozygous at all SNPs for the entire interval from the core region to the distance x .
Haplotypes slides stolen from Matteo Fumagalli
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Haplotypes iHs
Haplotypes iHs often | iHs | is used
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Haplotypes Exercises Let see how the haplotype methods works on famous examples of human adaptation (LCT). go to http://popgen.dk/albrecht/BAG2018/web/
Haplotypes

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Selection and haplotypes EHH statistics Anders Albrechtsen - PowerPoint PPT Presentation

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Selection and haplotypes EHH statistics Anders Albrechtsen - PowerPoint PPT Presentation

Selection and haplotypes EHH statistics Anders Albrechtsen Haplotypes Signature of selection Mutation enters the population Mutation increases in frequency due to positive selection Increases LD Affects the variability

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